Adaptive design: overview

Intro to adaptive design

Resources

• R package rpact and tutorial
• R package gsDesign and tutorial

Sequential design

Number of patient isn’t set in advance. A good group sequential design can reduce the sample size needed, while keeping the desired statistical power and controlling the overall type I error.

GSD includes pre-determined number of stages (interim, final). Each stage specified by

• sample size
• critical values
• stopping criterion to support or reject null hypothesis

TBC